It is due to a mutation in the gene encoding b1-tubulin and has been documented in several dog breeds.
• Cavalier King Charles Spaniel (According to research, this mutation in CKCS is prevalent in 90% of the population)
• Norfolk Terrier
• Cairn Terrier
• Labrador Retriever
• English Toy Spaniel
• Shih Tzu
• Jack Russell
• Cocker Spaniel και
• Bichon Frise
It leads to insufficient fragmentation of the cytoplasm of megakaryocytes resulting in the production of a reduced number of giant platelets. In asymptomatic CKCS and Norfolk Terrier dogs the platelet count counted with automatic haematological analyzers and / or optically numbered (peripheral smear) ranges from 30 to 150 x 10 g / μL. In Greyhounds the usual platelet count ranges from 80 to 295 x 10³ / μL, of hitherto unknown etiology.
Therefore in dogs of the above breeds with a significant reduction in PLTs and if they show bleeding and other manifestations such as petechiae – ecchymosis, nosebleeds, bleeding, gastrointestinal bleeding, hematuria, fatigue. anemic symptomatology, further investigation is recommended.
- Vet in Progress Plus
- Hematology Analyzer Operating Principles Illustrations