It is due to a mutation in the gene encoding b1-tubulin and has been documented in several dog breeds.

• Cavalier King Charles Spaniel (According to research, this mutation in CKCS is prevalent in 90% of the population)

• Norfolk Terrier

• Cairn Terrier

• Labrador Retriever

• Poodle

• English Toy Spaniel

• Shih Tzu

• Chihuahua

• Maltese

• Jack Russell

• Boxer

• Cocker Spaniel και

• Bichon Frise

It leads to insufficient fragmentation of the cytoplasm of megakaryocytes resulting in the production of a reduced number of giant platelets. In asymptomatic CKCS and Norfolk Terrier dogs the platelet count counted with automatic haematological analyzers and / or optically numbered (peripheral smear) ranges from 30 to 150 x 10 g / μL. In Greyhounds the usual platelet count ranges from 80 to 295 x 10³ / μL, of hitherto unknown etiology.

Therefore in dogs of the above breeds with a significant reduction in PLTs and if they show bleeding and other manifestations such as petechiae – ecchymosis, nosebleeds, bleeding, gastrointestinal bleeding, hematuria, fatigue. anemic symptomatology, further investigation is recommended.